Chris's Miraculous Journey / Recovery in China: Stem Cell Professionals

Tuesday, April 22, 2008

Stem Cell Professionals

Dr. Han Xiaodi, PHD,Director of Neurosurgery

Dr. Han Xiaodi is renowned worldwide for being one of the leaders in performing successful stem cell surgeries and therapies for patients suffering from a number of neurological disorders. Previous worked in the Department of Neurosurgery at the Alfred Hospital in Melbourne Australia.

Dr. Li Ke Wu, PhD,Director of Neurology Departmentl

Dr. Li Ke Wu is Director of the Nuerology Department at the Hospital. His research focus is on using stem cells to help patients overcome the effects of neurological degeneration diseases such as strokes, working to overcome mental diseases, electrophysiology, and more.

Dr. Wang Xiaojuan, PHD,Director of Neurology

Dr. Wang Xiaojuan is one of the world’s most experienced researchers of stem cell surgeries, treatments, and procedures. Her research focuses on using stem cells to help patients overcome the effects of neurological degeneration diseases, and has is one of Asia’s foremost experts on Cerebral Ischemia and brain injuries.

Who need the Stem cell treatment:

The stem cell treatments reflect wide range neurological diseases.

Post stroke patients
MSA, Parkinson Disease patients
Cerebral Palsy patients
Spinal Cord Injury
MS(multiple scierosis)
Muscular Dystrophy
Ataxia
ALS
Brain injury

What procedures are taken to insure the viability of the stem cells and their sterility?

Tiantan Puhua Neuroscience Hospital collaborates with Peking University’s SC Research Center & Lab (Beida), which is the most reliable laboratory in the country, especially for clinical purposes.

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Stem cell treatment for MSA/Parkinsons

Stem cell treatment for Parkinson

Parkinson disease is a brain disorder that occurs when certain nerve cells in the brain die or become damaged. The normal function of these nerve cells is the production of Dopamine – a vital chemical which is responsible of our body’s smooth and well coordinated movement. The lack of Dopamine as a result of damaged nerve cells can cause the Parkinson’s symptoms of shaking (tremors), stiffness of the muscles, freeze ups, balance difficulties and slowness of movement.

To treat Parkinson Disease we apply a unique procedure, specifically designed for Parkinson’s patients, in which we implanting through brain injection adult stem cells extracted from the human retina, called ‘human Retinal Pigment Epithelial cells’ (hRPE). These special cells have the quality of producing Dopamine which gives solution to the lack of Dopamine production which causes the symptoms of Parkinson Disease.
Another important advantage of these cells is that they have no immunosuppressive reactions and therefore patients do not need to take additional drugs during the treatment.

The treatment includes the implantation of hRPE cells into the region in the brain where the damaged cells are, along with a daily cocktail of medications that “fertilize” this area, helping the cells to survive and keep on renewing themselves.

While the treatment can not completely remove all symptoms of the disease, it can greatly reduce the tremors, decrease muscle tension, improve movement’s continuity and balance, increase the muscle strength, reduce the freeze ups, etc.

On June 2006 we have performed the first published successful stem cell treatment for Parkinson world wide, of an American patient that came to our hospital at a very progressive stage of Parkinson Disease.
You can find the Patient Experience of Penny Thomas at: http://www.stemcellschina.com/content/view/205/15/.

So far, about 20 Parkinson patients have been treated with hRPE stem cells from Peking University’s Stem Cells research Center (‘Beida’) in various cooperative hospitals. All of the patients showed increasing dopamine metabolism, and the conditions of the all the patients improved after the transplantation (usually the improvement occurred one week after the injection). The first clinical trial was performed at 2004, but long term following up is still under investigation (at least 1-3 years follow-up), so the treatment is still under careful control, especially in the selection of the suitable patients.

Our comprehensive program for Parkinson patients combines both nerve stem cell activation and stimulation and the stem cells implantation. This combined treatment has so far proved itself to be most efficient in bringing high level of recovery in different neurological diseases.
The treatment includes stem cell implantation, medications procedure, surgery procedure, biofeedback treatment and comprehensive rehabilitation.

The key to the success of this treatment method is the overall customized treatment regimen for each patient.

hRPE Stem Cells Implantation:

The hRPE cells will be injected through Sterotaxios surgery into the Putman area in the brain.
We use that technique since it has the highest accuracy.
A single injection of hRPE stem cells will be given to the patient.

Self Stem Cells Activation and Proliferation:

Under non-invasive circumstances, through daily IV of individually customized cocktail of neurotrophic medicines we activating the patient’s own stem cells and thus turning these cells into nerve precursor cells. These have signalization and migrate to lesions along the nerve developing-chord. Through this procedure we will create a most active and ‘fertile’
nerve environment in the brain, to allow the new implanted cells to survive, and to start a continuous process of renewing themselves.

Rehabilitation

Rehabilitation therapy is very much necessary as a part of the entire treatment regimen. In the past 20 years nerve system rehabilitation in terms of motor control theory has been greatly developed. The adult stem cell mobilization technique we use is combined with signal induction in the rehabilitation training procedure which can significantly improve brain function.

In our Rehabilitation center we use different kind of rehabilitation methods of Physical Therapy, Occupational Therapy, Speech therapy and Traditional Chinese Medicine.
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The Procedures

Self stem cell activation and proliferation program

This program usually takes six to eight weeks of stay in the Hospital.
1. Upon arrival at the hospital, you will be given standard tests to check your health and the details of your condition. A thorough evaluation of the neurological function and understanding of the lesion or pathological change in the brain tissues will be established by the medical team.
2. According to your condition a medical plan will be designed for Self Stem cell Original Activation and Proliferation treatment. Then, to drive off the triggers factors of the stroke, we will treat the blood vessel wall, the blood ingredients and the blood flow, improving the brain micro environment to help the stem cells proliferate.
3. The self activation and proliferation treatment will than start. Based on Neuro-endocrine immune network theory, we treat the patients by “waking up” the sleeping stem cells through oral medication. We use different medications during different processes (proliferation-inducement-differentiation), the medications always adjusted and combined; therefore, we call it ‘cocktail treatment’.
4. Through the treatment period we will be following up and evaluate your neurological function and improvement.
5. While one treatment cycle is complete, 2 to 5 months rest are recommended before coming for second treatment.

hRPE Stem cells implantation procedure by sterotaxios technology.

1． Preparation: You will be given enough time to recover after your trip before you will receive your first injection of stem cells. Some patients prefer to wait a day or two to get settled in before taking all the tests as they are quite thorough and can be strenuous after a long trip.
2． A sterotaxios frame is installed on the patient's head and he is then sent to CT or MRI scan with the frame.
3． The patient is sent to the operation room for surgery. The operation procedure:
The 3-D parameters of the injection target is calculated by 2 computers and related program to make sure of the accuracy of the surgery.
A sterile surgical guiding frame is installed that is connected with the head frame
A needle is them inserted under the guiding frame into the target by a tiny hole in the skull through which the stem cells are injected.

Chris's Miraculous Journey / Recovery in China

Tuesday, April 22, 2008

Stem Cell Professionals

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Because everybody deserves a wonderful life!!

Tiantan Puhua Hospitol Beijing

Chris Crane

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Stem cell treatment for MSA/Parkinsons